BHU TOPIC -REPEAT

McCune–Albright syndrome, described in 1937 by Donovan James McCune and Fuller Albright, is a genetic disorder of bones, skin pigmentation and hormonal problems along with premature puberty.
Contents
Symptoms

It is suspected when two of the three following features are present:

* (autonomous) endocrine hyperfunction such as precocious puberty
* Polyostotic fibrous dysplasia
* Café-au-lait spots

Presentation

Within the syndrome there are bone fractures and deformity of the legs, arms and skull, different pigment patches on the skin, and early puberty with increased rate of growth.

Polyostotic fibrous dysplasia has different levels of severity. For example one child may be entirely healthy with no outward evidence of bone or endocrine problems, enter puberty at close to the normal age and have no unusual skin pigmentation. The complete opposite of that would be children who are diagnosed in early infancy with the obvious bone disease and obvious increased endocrine secretions from several glands.

Approximately 20-30% of fibrous dysplasias are polyostotic and two thirds of patients are polyostotic before the age of ten.

Polyostotic fibrous dysplasia is usually caused by mosaicism for a mutation in a gene called GNAS1 (Guanine Nucleotide binding protein, Alpha Stimulating activity polypeptide 1).

The syndrome shows a broad spectrum of severity. The disease frequently involves the skull and facial bones, pelvis, spine and shoulder girdle. The sites of involvement are the femur (91%), tibia (81%), pelvis (78%), ribs, skull and facial bones (50%), upper extremities, lumbar spine, clavicle, and cervical spine, in decreasing order of frequency. The craniofacial pattern of the disease occurs in 50% of patients with the polyostotic form of fibrous dysplasia.






Q. Sezary syndrome progress to?
ans.Cutaneous T-cell lymphoma.

Sézary syndrome and mycosis fungoides are T-cell lymphomas whose primary manifestation is in the skin. The disease's origin is a peripheral CD4+ T-lymphocyte, although rarer CD8+/CD4- cases have been observed. Epidermotropism by neoplastic CD4+ lymphocytes with the formation of Pautrier's microabscesses is the hallmark sign of the disease. The dominant symptoms of the disease are:

Generalized erythroderma
Lymphadenopathy
Atypical T-cells ("Sézary cells") in the peripheral blood
Hepatosplenomegaly





Dieulafoy's lesion is a medical condition characterized by a large tortuous arteriole in the stomach wall that erodes and bleeds. It can cause gastric hemorrhage but is relatively uncommon. It is thought to cause less than 5% of all gastrointestinal bleeds in adults. It was named after French surgeon Paul Georges Dieulafoy, who described this condition in his paper "Exulceratio simplex: Leçons 1-3" in 1898. It is also called "caliber-persistent artery" or "aneurysm" of gastric vessels. However, unlike most other aneurysms these are thought to be developmental malformations rather than degenerative changes.


Dieulafoy's Lesions are characterized by a single large tortuous arteriole in the submucosa which does not undergo normal branching or a branch with caliber of 1-5 mm (more than 10 times the normal diameter of mucosal capillaries). The lesion bleeds into the gastrointestinal tract through a minute defect in the mucosa which is not a primary ulcer of the mucosa but an erosion likely caused in the submucosal surface by protrusion of the pulsatile arteriole.

Approximately 75% of Dieulafoy's lesions occur in the upper part of the stomach within 6 cm of the gastroesophageal junction, most commonly in the lesser curvature. Extragastric lesions have historically been thought to be uncommon but have been identified more frequently in recent years, likely due to increased awareness of the condition. The duodenum is the most common location (14%) followed by the colon (5%), surgical anastamoses (5%), the jejunum (1%) and the esophagus (1%). The Pathology in these extragastric locations is essentially the same as that of the more common gastric lesion.

Interestingly and in contrast to peptic ulcer disease, a history of alcohol abuse or NSAID use is usually absent in DL.

Symptoms
The symptoms due to bleeding are hematemesis and/or melena, possibly with shock.

Treatment
It is diagnosed and treated endoscopically, however endoscopic ultrasound or angiography can be of benefit.

Endoscopic techniques used in the treatment include epinephrine injection followed by bipolar electrocoagulation, monopolar electrocoagulation, injection sclerotherapy, heater probe, laser photocoagulation, hemoclipping or banding.





Dimorphic fungi are fungi which can exist as mold/hyphal/filamentous form or as yeast. An example is Penicillium marneffei:

* At room temperature, it grows as a mold.
* At body temperature, it grows as a yeast.

Several species are potential pathogens, including Coccidioides immitis, Paracoccidioides brasiliensis, Candida albicans, Ustilago maydis, Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii.

Dimorphic fungi are fungi that can reproduce as either a mycelial or a yeast-like state. Generally the mycelial saprotrophic form grows at 25° C, and the yeast-like pathogenic form at 37° C. Dimorphism is extremely important in the identification of mycoses, as it makes rapid identification of many pathogenic organisms possible. Some diseases caused by dimorphic fungi are

* sporotrichosis
* blastomycosis
* histoplasmosis
* coccidioidomycosis
* paracoccidioidomycosis
* penicillosis






Erythema Multiforme at a Glance
* Rare cutaneous and/or mucocutaneous eruption characterized by target lesions.

* Benign course but frequent recurrences.

* Most cases related to herpes simplex virus (HSV) infection.

* Frequent recurrences can be prevented by long-term use of anti-HSV medications

* M.pneumoniae is the second major cause of EM and may even be the major cause in pediatric cases.

* In cases related to M. pneumoniae the clinical presentation is often less typical and more severe than in cases associated with HSV.






MABs Used as Immunosuppressants and Anti-Inflammatory Agents

Adalimumab is a completely human IgG1 approved for use in rheumatoid arthritis.

Etanerceptis a dimeric fusion protein composed of human IgG1 constant regions (CH2, CH3, and hinge, but not CH1) fused to the TNF receptor.Etanercept is approved for adult rheumatoid arthritis, polyarticular-course juvenile rheumatoid arthritis, and psoriatic arthritis.

Infliximab is a human-mouse chimeric IgG1 monoclonal antibody possessing human constant (Fc) regions and murine variable regions. Infliximab is currently approved for use in Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.

Efalizumab is a recombinant humanized anti-CD11a monoclonal antibody approved for the treatment of adult patients with severe psoriasis.

Omalizumab is an anti-IgE recombinant humanized monoclonal antibody that is approved for the treatment of allergic asthma in adult and adolescent patients whose symptoms are refractory to inhaled corticosteroids .

Eculizumab is a humanized IgG monoclonal antibody that binds the C5 complement component, inhibiting its cleavage into C5a and C5b thereby inhibiting the terminal pore-forming lytic activity of complement. Eculizumab is approved for patients with paroxysmal nocturnal hemoglobinuria .

Palivizumab is a monoclonal antibody that binds to the fusion protein of respiratory syncytial virus, preventing infection in susceptible cells in the airways.






Neuroblastoma

Tumor Biology

Cytogenetic studies of neuroblastoma have demonstrated chromosomal abnormalities in most cases. The most common cytogenetic abnormalities in neuroblastoma aredouble-minute chromatin bodies (DM ), homogeneously staining regions (HSRs), and nonrandom deletion or loss of heterozygosity of the short arm of chromosome 1.
DMs and HSRs both represent cytogenetic manifestations of amplified sequences of the N-MYC cellular oncogene.Amplified N-MYC (more than 10 copies per cell) is a feature in approximately 30% of neuroblastomas.





PGMCET 2010 - All Sujectwise Questions

Anatomy :

1. Winging of scapula is due to paralysis of which muscle
Serratus Ant
Latissmus Dorsi
trapezius
supaspinatus

2. paramesonephric duct in males gives rise to
prostatic utricle
prostatic urethra

3. Which is not a tributary of Azygous Vein : R2007
Lt Superior Intercostal
Rt Superior Intercostal
Rt Post intercostal
Accesory Hemiazygous

4. Urogenital Diaphragm is formed by A/E :
Perineal membrane
Colle’s fascia
Deep transversus

5. meckels cartilage is derived from
2nd arch
1st arch
3rd arch
4th arch

6. the counter part of seminoma in females is
granulosa cell tumor
dysgerminoma

7. Erb’s palsy involves which part of Brachial plexus
Upper Trunk
Lower Trunk

8. Thoracic outlet syndrome nerve root involvement is:
C5 C6
C8 T1
C6 C7
C7 C8

9. Arch of Foot is maintained by :
Peronius brevis & peronius tertius
Peronius tertius & tibialis posterior
Peronius brevis & tibialis posterior

10. 6th arch N is :
Facial
Maxillary
RLN

11. Artery of 2nd Arch derivative is :
Maxillary
Stapedial

12. Thumb Joint between carpal & metacarpal is :
Saddle
Synovial
Primary Cartilaginous
Plain

Physiology :

13. Which of the Following involved in iron absorption is synthesized by liver & secreted thru bile in the intestine R2009
Apoferritin
Apotransferrin
Transferrin
All

14. laplace law all except
P = 2T / r
P = T / r
T = Pr / W
T = P / W

15. Which does not occur as the blood passes thru systemic capillaries R2007
Inc protein Content
Inc Heamatocrit
Dec pH
Shift of Hb dissociation curve to left

16. Satiety centre is located in
dorsomedial nucleus
ventromedial nucleus
lateral nucleus

17. pain sensation is carried fastest by
C type
A alpha
A beta
A delta

18. VC includes
IRV + ERV + TV
IRV + ERV + RV

19. Ohm’s Law (i-current, e-eletromotive force r-resistance)
i = e / r
I = r / e
None

20. Bruxism:
Stage II NREM
Stage I NREM
stage III NREM
REM

21. mean aortic pressure in newborn term baby:
40/60 mm Hg
75/50 mm Hg
80/40 mm Hg

22. spirometry cant measure
ERV
IRV
TV
RV

23. minimum urine osmolarity by normal kidney: Repeat
100 mosm
50 mosm
80 mosm
300 mosm

24. intraperitoneal pressure in laproscopy to prevent hypercapnia :
<11
<12
<13
<14

Biochemistry :

25. Formation os OKAZAKI fragments occurs in R2007
Transcription
Reverse Transcription
Translation
Replication

26. Acrodermatitis Enterpathica is caused by
Zinc
Selenium

27. Von Gierkes ds deficiency of enzyme :
Glu-6-phosphatase
Acid Maltase
Ms Phosphorylase

28. Not a Complex 4 poison in ETC is :
H2S
Cyanide
CO

29. fluoride causes inhibition of
enolase

30. Menke’s Kinky Hair disease :
Ceruloplasmin
Cu ATPase

31. besides protein what have catalytic activity:
DNA
RNA

32. chalones are:
regulator
operator
inhibitor
promoter

33. PCR tests for:
nucleotides
antigens
antibodies
all of the above

34. niacin derived from:
tryptophan
tyrosine

35. sulfur donor in phase 2 reactions:
PAPS
GSH
SAM

PHARMAC :

36. MOA Abciximab R2007
inhibitor of GPIIb IIIa
Inhibitor of adenosine reuptake
Anti thrombin III inhibitor

37. Anti malarial Drug causing Neuropsychiatric Adverse affects R2007
Artesunate
Mefloquine
Quinine
Artimisnin

38. sibutramine is which category of drug
cns stimulant
anorectics
cvs stimulant
pressor agent

39. Drug therapy used for Neuroleptic malignant Syndrome:
dantrolene
bromocriptine
nifedipine
all of the above

39. mechanism of action of imiquimod used in anogenital wart
improves the immune response
keratolytic
antifungal
antiviral

40. which opiod antagonist is given orally
naloxone
naltrexone
nalmifene
All

41. 5hT3 antagonist
Ondesetron
Cisapride
Metaclopromide

42. all hav active metabolites xcpt-
loratidine
azelastine
mizolastine
ebastine

43. reversible ototoxicity with:
clarithromycin
clindamycin
azithromycin
netilmicin

44. Action of NO are A/E: Modified R2006
Inhibits platelet aggregation by increasing cGMP
Inhibits platelet aggregation by increasing cAMP

45. least nephrotoxic :
gentamycin
streptomycin
amikacin

46. Drug or therapy C/I in WPW syndrome with Atrial fibrillation:
digitalis
amidorane
procainamide
DC cardioversion

47. glucocorticoid receptor antagonist
mifepristone
misoprostol
ketoconazole

48. drug not used in neuropathic pain :
Gabapentin
Opiods

49. not a K channel opener:
diazoxide
nicorandil
amiodarane
none of the above

PATHO :

50. Crescents on HP examination of Glomerulusseen in : R2002
RPGN
FSGS

51. Single Most indicator of likelihoodness of rapid progression of hepatitis to liver cirrhosis R2007
Serology
Etiology
Necrosis

52. increased mitotic index, starry sky appearance
burkitts lymphoma
MCL

53. most common cause of nephrotic syndrome in elderly:
minimal change disease
Ig A nephropathy
membranous nephropathy
none of the above

54. all are signs of reversible cell injury except :
mitochondrial swelling
membrane blebs
cellular swelling
nuclear shrinkage

MICRO :

55. Selective Media for N.Gonnorhea R2009.
Thayer Martin
Loefflers

56. Mycetoma caused by all except
Streptomyces somanliensis
Madurella Gresei
Phialophora jeanselmei

57. treponema pallidum was discovered by :
Robert Koch
shaudin nd Hoffman

58. ground glass hepatocytes in : Repeat
HAV
HBV
HCV
HDV

59. Medium for naegleria fowleri is :
non nutrient agar and e.coli
nutrient agar and e.coli

60. not a halophilic bacteria:
v.vulnificus
v.parahemoliticus
v.agenticus
v. murim

61. elek's test used in ELISA is for:
C. diphtheria

62. rhabtidiform larva is seen in:
strongyloides stercoralis
ankylostoma duodenale

63. Species of Klebsiella asso wid extremely Foul smell R2007
K rhinoscleromatis
K zygomaticus
K ozaenae
K seeberi

64. wet india ink preparation is for :
capsule

65. parasite causing myocarditis is R2008
trichuris trichura
trichinella spiralis
srtongyloidis stercoralis
ankylostoma

66. mebendazole is effective than albendazole in
trichiasis
ankylostoma duodenale
ascaris lumbricoides

67. tuberculate spores is characteristic found in R2008
blastomyces
histoplasmosis
coccidiomycosis
cryptoccosis

68. hand foot mouth disease(HFMD) is caused by R2008
parvovirus B 19
enterovirus 71

69. not a structural gene of HIV:
gag
tat
pol
env

70. malignant pustule seen in
B.anthracis
Ulcerans
Streptococcus

71. 100 mg mebendazole 2 doses will clear
ankylostoma
ascaris
enterobius
each of above

FMT :

72. Conjunctival Congestion, inc appetite, dry mouth, tachycardia R2009
Cannabis
Cocaine

73. marbling is seen in
36-48hrs
12-24hrs
24-36 hrs

74. Arborizing marks is seen in : R2005
Chemical Burn
Electric Burn
Lightening

75. cephalic index identifies :
race
sex
age

76. Surest Sign of defloration is :
Ruptured Hymen
Roomy Vagina

77. Paederasty involves unnatural offence between adult male & _____ as passive agent :
Young girl
Young boy

78. Doctor’s can examine a patient under emergency situation without consent under section :
91
92
93
94

79. OPD Records preserved by a private physician for :
1 yr
2 yr
3 yr

80. Poison causing Vesiculation is :
Cantharidine

81. La face sympathique seen in : Repeat
ante mortem hanging
post mortem hanging
Strangulation

ENT :

82. Abductor of vocal Cord R2009
Posterior Cricoarytenoid
Lateral Cricoarytenoid

83. all are seen in otosclerosis except : Modified R2002
deafness after 40 years of age
paracusis willisii
schwartz sign
vertigo

84. Masking phenomenon is due to:
all or none
post tetanic contractions
recruitement phenomenon

85. In Jarjaway #of nasal bone, # line is : R2007
Horizontally backwards
From front
Below

86. Opening of Eustachian tube is thru :
Tensor veli Palatini
Leavtor Veli Palatini
Salpingopharyngeus

87. caloric test for
Post semicircular canal
Lateral
Superior

88. M.C congenital stridor
laryngeal web
laryngomalacia

OPTHAL :

89. Snow Bank exudates R2007
Sympathetic opthalmia
Pars Planitis
Eale’s ds
Coat’s ds

90. gonoiscopy is use to measure
angle anterior chamber
lens
cornea

91. Most appropriate lens for cross cylinder wud be :
+0.5D Sphere & -1.0 D Cylinder
-0.5D Sphere & +1.0 D Cylinder
+1.0D Sphere & -0.5 D Cylinder
-1.0D Sphere & +0.5 D Cylinder

92. Amsler Grid is used in :
ARMD

93. Length of neonatal Eyeball is ____ of adult :
70 %
90 %
100 %

94. herberts pits is seen in
spring catarrh
neonatal conjuctivitis
trachoma

95. rate of aqueos flow :
0.8
0.6
0.4
0.2

96. raised IO tension no inflammation
glaucomatocyclitic crisis
PACG
POAG

PSM :

97. High Priority or transferable cases in TRIAGE color
Black
Red
Green

98 . Interval between reciept of infection by a host & maximum infectivity of that host
Generation time
median incubation period
general incubation period

99. 4 pairs of legs in which arthropods family
Insecta
Arachnida
Crustacea
All

100. all requires arthropod vector for transmission except R2007
Q Fever –
Rocky Mountain Fever
Scrub typhus
Epidemic Typhus

101. HDI involves All Ex R2002
Knowledge
Income
Longevity
Occupation

102. Scrub Typhus is caused by
R tsutsugamushi
R Prowazekii

103. India is in which stage of demographic cycle R2007
High Stationary
High Expanding
Low Stationary
Late Expanding

104. aftre vaccine rubella, how many months shd a woman not conceive
3 months
6 m
9 m
12 m

105. LBW of indian babies BW is less than R2007
2.2 kg
2 kg
2.5 kg
2.7 kg

106. RNTCP Tb Pericaritis shud be treated wid which CAT of AKT R2007
CAT I
CAT II
CAT III
CAT IV

107. Incubation Period of Mumps R2007
7-14
14-24
30-40

108. inhalation of sugarcane dust causes ? R2000, R2005
byssinosis
bagassosis
asbestosis
silicosis

109. chickenpox vaccine strain :
Edmonstan zagreb
Danish 1331

110. Nalgonda technique
REMOVING FLUORIDE
Removal of chlorine
Addition of chlorine

111. Claviceps fusiformis causes
aflatoxicosis
ergotism

112. millenium development goals is for which year
2015
2010
2020
2012

113. fertility indicator taking birth and mortality rate both in account is
net reproduction rate
general fertility rate
total fertility rate

114. daily intake of cal in a 15yr old child is
1150
1250
1450
1550

115. Upper Limit of Exposure to noise upto which der is no damage to hearing ? R2005
70 dB
85 dB
100 dB

116. Healthy Person who gets infection from another carrier is :
CONTACT
PSEUDO CARRIER

117. Under ESIS Act :
1.0 %
1.25 %
1.50 %
1.75 %

118. MEDICAL EDUCATION AND SUPPORT MANPOWER COMITTEE
SHRIVASTAVA COMMITTEE
Kartar Singh

119. OVER period of time which is used :
LINE DIAGRAM
Histogram
Pie Diagram
Bar Diagram

120. Energy Required in Below Poverty line ppl in rural is :
2100 Kcal
2200 Kcal
2300 Kcal
2400 Kcal

121. Leprosy is said to be eradicated when incidence in endemic areas is :
1/1000
1/10000
1/100000

122. specific dynamic energy maximum in
proteins
fat
carbohydrate
vitamin

123. cmi is strong in:
BL
BT
LL
tuberculoid Leprosy

MED :

125. In Alcoholics which vitamin shud be replenished wid carbohydrates R2009
B12
Riboflavin
Thiamine
Pyridoxine

126. Patau Syndrome Trisomy of
13
18
21

127. Lymphocyte Predominant & Rich Types similarity is
EBV causative in 40%
CD 20 +
RS Cells
excellent prognosis

128. Cells found in intestine are
paneth cells
neuroendocrine cells
stem cells
all of the above

129. Ordhnof sign present in ?
primary syphilis
secondary syphilis
tertiary
congenital

130. Megaloblastic Anaemia not responding to folic acid or B12 Rx is seen in R2007
Cirrhosis
Orotic Aciduria
Antconvulsant RX
All

131. H pylori associated with
Upper gastric carcinoma
carcinoma of fundus and cardia
carcinoma of 1 part of duodenum
carcinoma of GE junction

132. Fibrin Stabilizing Factor is
XI
HMWK
XII
XIII

133. SLE causes
Lymphopenia
Neutropenia
Eosinopenia
all of above

134. pO2 satisfactory in pulse oximetry:
80%
90%
70 %
100 %

135. Diacrotic Pulse differ in Pulsus Bisferiens in R2007
2 palpable waves one in systole & other in diastole
2 palpable waves both in systole

136. IRF is characterized by all except R2007
RF index more than 1
FeNa less than1 %
U. Na more than 20 mmol
Uc : Pc less than 20

137. homocytotropism seen with:
Ig G
Ig A
Ig M
Ig D

138. D-dimer is seen in :
Pulmonary Embolism
MI
Pulmonary Oedema
All

139. MEN1 most characteristic feature :
Hyperparathyroidism
Gastrinoma

140. difference between renal osteodystrophy and nutritional osteomalacia:
hypocalcemia
hyperphosphatemia
hypercalcemia
none of the above

141. MEN 2A characteristic feature is :
MTC
Pheochromocytoma
Hyperparathyroidism

142. episodic hypertension seen with:
phaeochromocytoma
cushing's syndrome
conn's syndrome

143. MDR therapy of TB while giving AKT coz :
It reduces the dosage
Less duration of treatment

144. ecg in acute cor pulmonale:
S1Q3T3 wave pattern
afib
slow progressn of r waves
all of the above

145. site of action of PTH:
PCT
DCT
ascending limb of loop of henle
all of the above

146. The diagnosis in a person having hypertension and hypokalemia with a suprarenal mass of 7 cm:
Adrenal carcinoma
Cushings syndrome
Phaeochromocytoma
Conn’s syndrome

147. Klienfelter syndrome is :
47 XXY
47XYY
45 XO

148. tendon ganglioma is
myxematous degeneration
neural neoplasia

SURG :

149. strangulation is common in
richters hernia
femoral hernia
inguinal hernia

150. Strawberry GB : R2007,R2005
Adenomyomatosis
Cholesterosis
Porcelain GB

151. Simple Rib # shud be treated wid A/E : R2007
Analgesics
PT
Early ambulation
Chest strapping/bandaging

152. cleft palate surgery for soft palate done at:
12 months
9 months
6 months
3 months

153. sarcomatous change is associated with:
increase in size
pain
bleeding
all of the above

154. M.C feature on benign breast Ca on usg
Microcalcification
popcorn pattern

155. M.C site of intraperitoneal abscess collection
Subhepatic
Paracolic
pelvic

156. Non Absorbable suture is :
Polypropylene
Catgut

157. well defined lesion with sooth margins and coarse calcification in lung :
hamartoma
adenoma
ca bronchus

158. mondors disease
superficial thrombophlebitis

OBGY :

159. toxoplasmosis is harmful in which trimester
1st trimester
2nd
3rd
Same in all trimester

160. Lovsets maneuvre in breech presentation
extended legs
extended arms
anterior shoulder

161. most unfavourable presentation is
occipito posterior
mento posterior

162. t1/2 of oxytocin
9 min
7min
3min
< 1 min

163. hot flushes after menopause caused d/t
estrogen
FSH
LH
Progesterone

164. chadwick sign :
blue Vagina

165. conservative t/t ectopic tubal pregnancy
salpingostomy
salpingectomy

166. Yuzpe's method used for :
Natural IUCD Contraception
Natural Hormonal Contraception

167. Natural Suture for Uterus :
Inner layer of myometrium
Middle Layer of Myometrium
Endometrium
Perimetrium

168. 1st sign of puberty
Thelarche
Pubarche
Menarche
Growth

169. Manchester Sx is for :
Ca Cx

170. APGAR SCORE includes all except (Well this Q says APGAR Score & options of Bishop’s Score…Wrongly framed Q by setter)
Station head
interspinous diameter
Dilatation
Effacement

171. if baby not coming out what shd be done
fundal pressure
traction on head
traction along long axis
pulling out thru shoulder

PAEDS :

172. size of endotracheal tube in a 1500gm baby is
2.5
3
3.5
2

173. pre term baby mothers milk is deficient in
proteins
fats
lactose

174. A child can sit without support, speak mono syllables & transfer objects from one hand to another by what age
3 mths
6 m
9 m
12 m

175. In Kwashiorkar letter K is post Fixed to indicate : R2006
Edema
Weight for Height
Muscle Wasting
Skin Changes


SKIN :

176. coral red colour on woods lamp occurs in R2008
erythrasma
ptyriasis rosea
erysipelas

177. Munro’s Microabcesses seen in:
Psoriasis
Lichen Planus

178. erythema multiforme seen in all except.....
leprosy
h.simplex
sulfonamide
mycoplasma

179. Chancroid is caused by : R2003,R2006
H. ducreyi
Donovania granulomatis

180. Not A Skin TB is :
Scrufuloderma
Lupus Vulgaris
Granuloma Annulare

181. not a NRTI
Nevarapine
Zidovudine
Lamivudine
Abacavir

Anaesthesia :

182. MR given in pt wid liver & renal Disease
Atracurium

183. which local anaesthetic produces methaemogloginaemia in children
lignocaine
bupivacaine
prilocain

184. which drug is eliminated by "hoffman’s elimination" and ester hydrolysis R2007,R2002
pancurium
vecorium
mevacurium
Atracurium besylate

185. Dissociative Anaesthesia is seen in which drug R2002,R2005
Ketamine
Propofol

186. What should be the internal diameter of the ENDOTRACHEAL TUBE in a child weighing 1500 gms ? R2007
2 mm
2.5 mm
3 mm
3.5 mm

187. Color of NO cylinder is : R2002
White wid blck shoulders
Orange
Blue
Grey

RADIO :

188. String of Beads Sign
CHPS
Crohns
Fibromuscular Dysplasia

189. the SI unit of absorption dose in radioactivity is : R2006
rad
rem
gray
Curie

190. double bubble sign appearance : R2006
duodenal atresia

191. best method to visualise MECKELs DIVERTICULUM pre-op?
usg
barium enema follow thru
Tc 99 scan
xray

192. x ray for infant of 7 months diagnosed by:
Wrist
Elbow
Knee
Clavicle

Psychiatry :

193. Bleuler’s four A of schizophrenia are A/E R2007
Autism
Affect
Anhedonia
Association

194. Diagnosis of Major Depression : R2007
Loss of interest or pleasure
Insomnia
Recurrent suicidal ideation

195. Mature Defence mechanism in OCD :
Reaction formation
Humor
Sublimation
Suppression

196. MMSE maximum score is :
26
30
34
36

197. when rhyming words are used:
Flight of Ideas
clang association

orthopaedics :
198. CTEV all except
more common in males
eversion
adduction
flexion
199. benetts fracture occurs in R2000
1st metacapal
2nd metacarpal

200. anterior drawer test is use to detect
ACL tear
PCL tear

201. tumor which is metaphyseal, expansile, filled with fluid, more common in female is
osteoclastoma
chondroblastoma
bone cyst

202. anterior drawer test is used for :
ACL
PCL

203. Most Common benign tumour of bone is : R2007
Osteoid osteoma
Chondroblastoma

204. Looser’s Zone is/are seen in : Modified R2003
Osteogenesis Imperfecta
Paget’s disease
Osteomalacia
All

205. Dinner Fork Deformity is seen in # of: R2005, R2003
Radius
Ulna
Carpal
Metacarpal

206. child <4 yrs old with osteomyelitis causative agent:
s.pneumoniae
salmonella
e.coli
h.influenzae

207. tom smith arthritis involves:
hip joint
knee joint
elbow joint
shoulder joint

208. Ulnar Nv damage occurs at :
Medial Condyle
Medial Epicondyle
Lateral Epicondyle

ADDITIONAL Qs :

209. MNG + rapid incr in size + hoarseness of voice
follicular
Anaplastic
Papillary
Medullary

210. Globular Heart wid Pulmonary oligemia :
TAPVC
TGA
VSD

211. Wilson’s Ds :
Short arm of Ch 6
Long arm Ch 6
Short arm Ch 13
Long arm Ch 13

212. not usually painful:
chancroid
herpes genitalis
donovanosis

213. MCC of CAH
21 alpha hydroxylase def
17 beta hydroxylase def

214. lady with hypogonadism n prim amen
Turner’s
Kallman’s
Klinefelter’s

215. drug which inhibit cholestrol absorption
exetimibe
Nicotinic Acid

216. drug acting on all the stages of plasmodium falciparum :
PRIMAQUINE
MefloQuine

217. manning score in normal delvery :
8-10
4 -6
7 – 8

218. most common cause of uterine rupture
LSCS Scar

219. 2D ECHO UP AND DOWN MITRAL Flow
AORTIC REGURGE
MR
PR
TR

220. isolated increase in ALP in abscence of liver disease or raised serum bilirubin is seen in :
inflamm bowel disease
all of above

221. decreased leukocyte alkaline phosphatase scores are seen in all except:
CML
paroxysmal nocturnal hemoglobinurea
dermatitis keratoplasia
all of the above

222. multiple myeloma hyperviscosity is due to:
Ig G
Ig A
Ig D
Ig M

223. Neglaer reaction
Cl . septicum
Cl. Perfringens

224. PAM not for carbamate :
cant bind esteric site
cant bind anionic site

225. Pulmonary plaque + fibrosis on base of lung :
Asbestosis

226. cross resistance AKT :
INH
Streptomycin
Rifampicin
Ethionamide

227. Which Dissapears with time :
Strawberry Angioma
Port Wine Stain

228. At 21 C wid 80 % humidity maximum heat loss is by :
Convection & Radiation
Quiet respiration
Skin Sweating
229. Glomerulus of Cerebellum :
Granular Layer

230. Sleep Apnoea is present for:
1 sec
3 sec
5 sec
>10 sec

231. reversal of non depolarizing :
neostigmine
pyridostigmine
physostigmine

232. p53 characteristic
Acts on p21
apoptosis
Combination with specific p53 oncovirus
All the above

233. berlins edema :
After cataract
concussion injury

234. structure in central lobule of hepatocyte :
hepatic vein
Portal Vein

235. receptors for fall in bp located in :
rt. Atrium
lt. atrium
pulmonary art
all







PostPosted: Thu Jan 28, 2010 1:39 pm Post subject:
1.which must be present for diagnosis of major depression ?
Loss of pleasure/anhedonia

2.Least nephrotoxic - streptomycin

3.millenium development goals - 2015

4.Causing myocarditis - trichinella

5.Act in good faith by a doctor - sec 92

6.calymmatobacterium granulomatis causes donovanosis

7.paramesonephric duct - prostatic utricle

8.ESIC - 1.75 PERCENT OF INCOME

9.HOFFMAN - ATRACURIUM

10.METH Hb - PRILOCAINE

11.suture non absorbable – POLYPROPYLENE

12.VC = ERV + IRV + TV

13.MANCHESTER = CA CERVIX

14.Opener of eusthacian tube = Tensor veli palati

15.La facie sympathique = ante mortem hanging

16.treponema pallidum-shaudin nd hoffman

17.rhabtidiform larva-strongyloides

18.Naeglerai fowleri = NON-nutrient agar + ecoli

19.CLAVICEPS---- ERGOTISM

20.all hav active metabolites xcpt—MIZOLASTINE

21.dicrotic pulse - one in syst one in diastole

22.WILSON’S DISEASE---13Q

23.menke hair disease---- CU ATPASE

24.glucocorticoid receptor antagonist-mifepristone

25.diagnosis in a person having hypertension and hypokalemia with a suprarenal mass of 7 cm:--ADRENOCORTICAL CARCINOMA

26.Klinefelter xxy

27.2nd arch artery stapedial

28.patient record for 3yrs

29.progression of labour 3hr

30.peadetry-young boy

31.Borderline pesonality disorder

32.amotivation syndrome-cannabis

33.strawbarry angioma-spontaneous regress

34.strawberry gall bladder-cholesterosis

35.meinter cartilage-1st arch

36.reversible hearing loss-clarithromycin

37.nevirapin-nuceosides except

38.low pressure receptor-all

39.post.cricoarytenoid-abductor

40.Smoking -all

41.nerve of 6th arch-recurrent laryngeal nerve

42.Congenital dislocation of hip-Bartolini test

43.Hand foot mouth syndrome-enterovirus 71

44.dinner fork deformity-radius

45.intestinal cells-all

46.seminoma counterpart in female-dysgerminoma

47.hot flushes-rx with estrogen

48.pellagra-leucine excess

49.ohms law i=e/v

50.turner syndrome-hypogonadism amenorrhea

51.Radical Therapy for P.falciparum - 3 days

52.Not included in HDI - Occupation

53.Nalgonda technique - FOR REMOVING FLORIDE

54.Leprominntest positive in - TT

55.D-dimer increased in P.embolism/ami/*/all the above - ALL

56.orndorf sign -sec syphilis

57.Incubation Period of Mumps - 14-24 days

58.Tetanus eliminated if less than /10000 births - 10

59.neuropsychiatric side effect seen with.......mefloquine

60.erb's palsy.....injury to upper trunk

61.tardy nerve palsy seen in......... # of lateral condyle humerus

62.winging of scapula........... due to paralysis of serrateus antr

63.Thoracic outlet syndrome.................due to compression C8, T1 nerve root

64.suprarenal gland drain into... para aortic lymph nodes

65.Urogenital diaphragm is formed All Excep - Colle’s fascia

66.Not included in TB = granuloma annulare

67.Amsler's grid = Acute Retinal Macular Degeneration

68.elek's test- diphtheria

69.Nagler's reaction is Cl.perfringes

70.wet india ink- capsule

71.Drugs used in parkinsons - all

72.Acrodermatitis entepathica...Zinc

73.Von Gierke's diseasese...Glucose 6 phosphatase

74.GpIIbIIIa - abciximab

75.Pulmonary plaque..Asbestosis

76.sugarcane = bagassosis

77.Dissociative Anaesthesia ...Ketamine

78.Color of NO2 cylinder...Blue

79.N.gonococci - Thayer Martin medium

80.ulnar nerve = medial epicondyle

81.Crescentic Nephritis - RPGN

82.Most common Congenital Adrenal Hyperplasia - 21 alpha hydroxylase def

83.Benett's fracture intra-articular - first metacarpal

84.CORAL RED ON WOODS LAMP - ERYTHRASMA

85.eyeball length at birth - 70%

86.India is in - LATE EXPANDING PHASE

87.MEDICAL EDUCATION AND SUPPORT MANPOWER COMITEE - SHRIVASTAVA COMMITEE

88.snow banking - pars planitis

89.5HT3 - Ondansetron

90.ground glass hepatocytes in -Hepatitis B

91.gonioscopy - ant chamber

92.neuroleptic syndrome-all of the above

93.PPAR - thiazolidinediones

94.Spirometry does not measure - Residual Volume

95.triage most priority-red

96.micro munro abcess psoriasis

97.best investigation for diverticulum - Tc 99 scan

98.string of beads fibromuscular dysplasia

99.ant drawer test -ant cruciate ligament

100.Half life of oxytocin on iv administration ans is 3 mins

101.sleep apnoea >10 secs

102.Bruxism- stage III NREM

103.true Bn Bone tumour- Osteoid Osteoma

104.Chadwicks sign - bluish discol'n

105.Surest sign of defloration- roomy vagina

106.Starry sky appearance - Burkitt's Lymphoma

107.malignant pustule seen in-B.anthracis

108.nasopharyngeal CA -NON KERATINISING squamous cell

109.brachytherapy-near the affected organ

110.Breast ca -microcalcification

111.sibutramine - anorectic

112.imiquimod - immunostimulant

113.simple rib # is treated by a/e - chest strapping

114.niacin derived from....tryptophan

115.flouride inhibits..... enolase

116.satiety centre....ventromedial nucleus

117.arterial pressure in newborn - 60/40mm of Hg

118.cephalic index -identify race

119.All are features of CTEV except - eversion

120.bishops score not included - interspinous diameter

121.Capillary changes in blood except - Shift of O2 dissociation curve to the left

122.structure in centre of portal lobule - Portal vein

123.Tom Smith's arthritis - hip








1. MOST ACCURATE TEST TO DIAGNOSE SYPHILLIS.....
2. CULTURE MEDIA FOR ENTAMOEBA....
3. COMMONEST COMPLICATION OF PSORIASIS.....
4. WHAT HAPPENS TO THE OSMOTIC AND HYDROSTATIC PRESSURE IN RPGN.....
5. ENUMERATE CAs PRODUCING HYPERTROPHIC OSTEOARTHROPATHY....
6. NBT-PABA TEST IS USED FOR.....
7. ASA STANDS FOR.....
8. HELIOTROPIC RASH IS FOUND IN.....
9. NORMAL LH/FSH RATIO....
10. WATER LILY APPEARANCE IS FOUND IN.....
11. HIGHEST NERVE IN POSTERIOR TRIANGLE....
12. VEINS DRAINING CAVERNOUS SINUS......
13. GREEN COLOUR OF BRUISE MEANS THE AGE OF INJURY IS....
14. COMMONEST ADR OF SUMATRIPTAN....
15. WHICH ANTINEOPLASTIC DRUG REACTS WITH DNA DIRECTLY A)MTX B)CYCLOSPORINE
C)5-FU D)VINCA ALKALOIDS
16. COXA VERA DEFORMITY AFFECTS WHICH BONES....
17. HOW MUCH LENGTH OF RECTUM IS SPARED IN ANTERIOR RESECTION OF RECTUM?
(CHOICES WERE IN cms.)
18. WHAT IS T/T OF PROSTATIC CALCUS?
19. ADRS OF MESOPROSTOL.....
20. WHAT ARE TYPES OF HIV1.....
21. AXN OF 1FN-6.....
22. GORDON'S SYNDROME.....
23. LEADING QUESTIONS ARE ALLOWED IN WHAT PART OF TRIAL...
24. LEAST MALIGNANT MELANOMA IS...
25. RT. BORDER OF HEART IS FORMED BY.....
26. MAX. NO. OF BORDETELLA ARE FOUND IN A)CATARRHAL STAGE B)FULMINANT STAGE
C)LATENT STAGE
27. CARPAL BONES OSSIFY BY WHAT AGE....
28. AXN OF LUMBRICALS......
29. USE OF GABAPENTIN.....
30. TOURETTE SYNDROME.....
1)TPI MOST SPECIFIC
FTABS MOST SENSITIVE
2)BALAMUTH'S MEDIUM
ROBINSON'S MEDIUM
EGG SLANT -LOCKES SOLUTION DIPHASIC MEDIUM
8)DERMATOMYOSITIS
10)HYDATID CYST
16)FEMUR
23)CROSS XAMINATION
24)LENTIGO MALIGNA MELANOMA
28)FLEXION MCO EXTENSION IP JOINTS
30)DOC HALOPERIDOL





1. Which is not a complication of Diabetes complicating Pregnancy ?
A) Duplex Ureter
B) Renal Agenesis
C) Chromosomal Abnormalities
D) Sacral Agenesis

Ans: C) Chromosomal Abnormalities
[Ref: William's Textbook of Obstetrics]


2. Treatment of choice in Prostatic Calculi is ?
A) No treatment necessary
B) Suprapubic prostatectomy
C) Trans urethral prostatectomy
D) ESWL

Ans: A) No treatment necessary
[Explanation -
Treatment of choice - No treatment necessary. If however, treatment needs to be done, it is Transurethral prostatectomy]


3. Radioactive Scintigraphy is done in which type of Diverticulitis ?
A) Sigmoid diverticulitis
B) Jejunal diverticulitis
C) Ileal diverticulitis
D) Meckel's diverticulitis

Ans: D) Meckel's diverticulitis


4. Most common site of atresia in the Gastrointestinal tract is ?
A) Ileum
B) Duodenum
C) Jejunum
D) Colon

Ans: B) Duodenum


5. Meckel's diverticulum is a remnant of ?
A) Vitello-Intestinal duct

Ans: A) Vitello-Intestinal duct


6. Most common cause of Stress Urinary Incontinence is ?
A) Increased intra-abdominal pressure
B) Trauma during child birth
C) Congenital

Ans: B) Trauma during child birth


7. Neural Tube closes at ?
A) 3rd day
B) 25 - 27th day of embryonic life
C) 17th day of embryonic life



8. Commonest complication of SLE is ?
A) Haematological
B) Renal
C) Liver (Hepatic)

Ans: A) Haematological

[Ref: Table 311-2, Harrison's 15th Ed]

9. Primary Amyloidosis does not involve which site ?
A) Tongue
B) Kidney
C) Heart
D) Liver

Ans: ?

[Note:
According to Harrisons's Table 319-2 all of the above are involved in Primary Amyloidosis]

10. Treatment of choice in Common Bile Duct stones is ?
A) Laparoscopic surgery
B) Common Bile Duct Exploration
C) Stent insertion
D) ERCP

Ans: D) ERCP

11. Botulinism is diagnosed by ?
A) Blood
B) Stool
C) Urine
D) Jejunal biopsy

Ans: B) Stool
[Explanation -
Diagnosis of Botulism -
o Demonstration of Toxin -
? This is the most important laboratory test
? Diagnosis is confirmed by demonstration of the toxin in the specimens after inoculation into mice, rats or guineapig.
? Specimens include - Stool, food or vomitus
? They are macerated in sterile isotonic saline and the filtered extract is divided into three parts.
? One portion is heated at 100 C for 10 mins
? Two mice are injected intraperitoneally each with 2 cc of unheated filtrate; one of which is protected with polyvalent botulinum antitoxin.
? The third animal is injected with 2 ml of heated material.

? The Unprotected animal develops dyspnoea, flaccid paralysis and dies within 24 hours of injection
? 2nd and 3rd animals do not show any toxic symptoms.
o Demonstration of Organisms -
? Smears from feces / intestinal contents / suspected food - Stained with gram stain (which may show gram positive sporing bacilli)
? Culture of specimens - On blood agar / cooked meat media. Followed by detection of toxin in culture fluid by toxigenecity test in mice.
The mere presence of bacilli in food / feces in absence of toxin is of no significance
12. The commonest cause of Acute Pancreatitis is ?
A) Alcohol
B) Gall stones
C) Idiopathic
D) ERCP

Ans: B) Gallstones
[Explanation -
Etiology of Acute Pancreatitis -
o Biliary Calculi (50 - 70%) - i.e. commonest
o Alcohol (25%)
o Rare causes
o Idiopathic
Ref: Bailey & Love, 23rd Ed, Pg-996]

13. Painless hematuria occurs in ?
A) Renal Stones
B) Renal Cell carcinoma
C) Polycystic Kidney Disease

Ans: B) Renal Cell Carcinoma

14. Which will be present in Chylomicrons ?
A) apo B 100
B) apo A
C) apo E
D) apo G

Ans: C) apo E

15. WHICH ANTINEOPLASTIC DRUG REACTS WITH DNA DIRECTLY ?
A) MTX (Methotrexate)
B) CYCLOSPORINE
C) 5-FU
D) VINCA ALKALOIDS
Ans: C) 5-FU


16. WATER LILY APPEARANCE IS FOUND IN..... ?
Ans: Hydatid Cyst


17. MOST ACCURATE TEST TO DIAGNOSE SYPHILLIS..... ?
Ans: Treponema Pallidum Immobilization test (TPI test)


18. COXA VERA DEFORMITY AFFECTS WHICH BONES.... ?
Ans: Femur & Pelvis


19. ASA STANDS FOR..... ?
Ans: Amino Salicylic Acid


20. LEADING QUESTIONS ARE ALLOWED IN WHAT PART OF TRIAL... ?
Ans: Cross Examination


21. CULTURE MEDIA FOR ENTAMOEBA.... ?


22. COMMONEST COMPLICATION OF PSORIASIS..... ?


23. WHAT HAPPENS TO THE OSMOTIC AND HYDROSTATIC PRESSURE IN RPGN..... ?


24. ENUMERATE CAs PRODUCING HYPERTROPHIC OSTEOARTHROPATHY.... ?


25. NBT-PABA TEST IS USED FOR..... ?


26. HELIOTROPIC RASH IS FOUND IN.....?


27. NORMAL LH/FSH RATIO.... ?


28. HIGHEST NERVE IN POSTERIOR TRIANGLE.... ?


29. VEINS DRAINING CAVERNOUS SINUS......?


30. GREEN COLOUR OF BRUISE MEANS THE AGE OF INJURY IS.... ?


31. COMMONEST ADR OF SUMATRIPTAN.... ?


32. HOW MUCH LENGTH OF RECTUM IS SPARED IN ANTERIOR RESECTION OF RECTUM? (CHOICES WERE IN cms.) ?


33. ADRS OF MESOPROSTOL..... ?


34. WHAT ARE TYPES OF HIV1..... ?


35. AXN OF 1FN-6..... ?


36. GORDON'S SYNDROME..... ?


37. LEAST MALIGNANT MELANOMA IS... ?


38. Right Border of the Heart if formed by ?


39. MAX. NO. OF BORDETELLA ARE FOUND IN ?
A) CATARRHAL STAGE
B) FULMINANT STAGE
C)LATENT STAGE


40. CARPAL BONES OSSIFY BY WHAT AGE.... ?
Ans: 12 years (pisiform is last to ossify by the age of 12 years ?)


41. AXN OF LUMBRICALS...... ?


42. USE OF GABAPENTIN..... ?


43. TOURETTE SYNDROME..... ?